Содержание
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Alzheimer disease andother mental impairments
Medications for Alzheimer disease Zvereva Mila school of pharmacy
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Cognitive impairment
Neurodegenerative diseases Vascular diseases Combined (neurodegenerative-vascular) diseases Dismetabolic encephalopathy and intoxications Neuroinfections and intoxications Traumatic brain injury Brain tumor Liquor dynamic impairments
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Preclinical Alzheimer disease
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Mild Alzheimer disease
Memory loss Confusion about the location of familiar places Taking longer to accomplish normal, daily tasks Trouble handling money and paying bills Compromised judgment, often leading to bad decisions Loss of spontaneity and sense of initiative Mood and personality changes; increased anxiety
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Moderate Alzheimer disease
Increasing memory loss and confusion Shortened attention span Problems recognizing friends and family members Difficulty with language; problems with reading, writing, working with numbers, studying Difficulty organizing thoughts and thinking logically Restlessness, agitation, anxiety, tearfulness, wandering, especially in the late afternoon or at night Hallucinations, delusions, suspiciousness or paranoia, irritability Loss of impulse control Perceptual-motor problems
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Severe Alzheimer disease
Weight loss Seizures, skin infections, difficulty swallowing Groaning, moaning, or grunting Increased sleeping Lack of bladder and bowel control Completely dependent on others for care
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Ethiology
Advancing age Family history APOE 4 genotype Obesity Insulin resistance Vascular factors Hypertension Inflammatory markers Down syndrome Traumatic brain injury
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Prevention
Physical activity Exercise Cardiorespiratory fitness Mediterranean diet
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Management
Antidepressants Anxiolytics Antiparkinsonian agents Beta-blockers Antiepileptic drugs Neuroleptics
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Cholinesterase Inhibitors
Donepezil (Aricept, Aricept ODT) Rivastigmine (Exelon, Exelon Patch) Galantamine (Razadyne, Razadyne ER)
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N-Methyl-D-Aspartate Antagonists
Memantine (Namenda, Namenda XR)
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Nutritional Supplement
Caprylidene (Axona)
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The End
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